dbNSFP - Releases

Current Release: dbNSFP v5.1 (March 21, 2025) (Highlights, README v5.1a, README v5.1c, Change Log)

Rebuilt variant set (all potential nsSNVs and ssSNVs) based on latest GENCODE release 47 (Ensembl v113).
Added Allele frequencies from All of Us (250k genomes) and Regeneron Genetics Center Million Exome (RGC-ME) (Thanks to Moez Dawood and Dr. Richard Gibbs from HGSC at Baylor College of Medicine).
- Please note RGC-ME allele frequency data is only available in v5.1a for academia use only.
Added dbNSFP_POPMAX_AF/AC etc. based on all population allele frequency columns curated in dbNSFP.
Updated MutationTaster2021 to include more missense mutations (Thanks to Franziska Fritz and Dr. Dominik Seelow from Berlin Institute of Health).
Other updated resources include Clinvar, GWAS catalog, OMIM, Orphanet, ClinGen Dosage Sensitivity, Interpro, HGNC, Uniprot, IntAct, Gene Ontology, MGI, ZFIN, UniParc, RefSeq, MANE, and HPO.
Provided dbNSFP files in a format ready to use with Ensembl Variant Effect Predictor (VEP) (Thanks to Dr. Jamie Allen from EMBL-EBI) and SnpSift.

History Releases

dbNSFP v5.0 (January 1, 2025) README

Fully rebuilt based on GENCODE release 46/Ensembl 112
Transcripts annotations from the MANE project has been added.
Allele frequencies from TOPMed freeze8, and gnomAD exome controls, non-neuro, and non-cancer subsets from v2.1.1 have been added.
Allele frequencies from gnomAD have been updated to v4.1 joint data set (genome+exome).
bStatistic, ancestral alleles, and ClinVar have been updated.
MutationTaster has been updated to MutationTaster2021.
The gene table has also been rebuilt. ClinGen Dosage Sensitivity and Humnan Protein Atlas consensus gene expression levels have been added.
HGNC, Uniprot, IntAct, GWAS catalog, Interpro, Gene Ontology, ConsensusPathDB, HPO, mouse homolog genes, zebrafish homolog genes, HPO, OMIM, Orphanet have been updated.
The egenetics and GNF/Atlas expression, gene interactions and SORVA statistic have been retired.
LRT, FATHMM, fathmm-MKL, fitCons, LINSIGHT, GenoCanyon, EVE, Siphy scores, allele frequencies from ESP, ExAC, UK10K, and GTEx, eQTLGen and Geuvadis eQTLs have been retired.

For versions (1.x - 4.x), please refer to legacy dbNSFP website here.

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