Download

• dbNSFP is free for academic and non-commercial use under the CC BY-NC-ND 4.0 license. 

  • Please register first using your academic institutional email to receive the dbNSFP Access Code and download links.

  • Previously registered users can re-use the Access Code to request download for the latest versions of dbNSFP going forward.

• License fees apply if dbNSFP is used in products or services that are sold or monetized. This licensing model ensures the continued development and maintenance of dbNSFP resources for both academic and industry users. Please refer to License page for the FAQ and instructions on obtaining a commercial use license for dbNSFP.

Data format

• dbNSFP traditionally includes per-chromosome files bundled with search_dbNSFP Java program (Usage), which can search for SNVs in various formats and genome builds. 

• We aim to maintain this file format for dbNSFP to minimize the work needed for using the latest dbNSFP data with existing tools and platforms.

• Additionally, we also provide dbNSFP in BGZF format, ready to use with VEP and SnpSift.

Web Service

• We also provide a web service for the convenience of end users to search variants in the current version of dbNSFP data online. 

• Academic users can access this service for free using the Access Code following registration.