dbNSFP Data Format and Usage
We provide full dbNSFP data download in a zip file including variant tables by chromosome, gene table and search_dbNSFP annotation program.
dbNSFP 5.x maintains the same file formats as used in 4.x to be compatible with the existing software systems using dbNSFP data.
We recommend using the search_dbNSFP annotation program to access the full annotation functions provided by dbNSFP and for its performance benefit when annotating a large number of variants.
Additionally, we provide the dbNSFP variants table in BGZF format, which can be used directly with Ensembl VEP and SnpSift.
Academic Use
dbNSFP academic branch is free for academic and non-commercial use under the CC BY-NC-ND 4.0 license.
Academic users can download full dbNSFP data for free: please register with an academic institutional email and request download links.
Academic users can also search and explore full dbNSFP variant and gene data in dbNSFP Web Service without the need to download.
Some dbNSFP data (may not be up-to-date though) can also be accessed through our partners at Ensembl VEP web version, OpenCRAVAT, ANNOVAR, KGGSeq, VarSome, UCSC Genome Browser's Variant Annotation Integrator, SnpSift and HGMD.
Commercial Use
A license is needed for commercial use of dbNSFP (c-branch). This model ensures the sustainable, long-term development of dbNSFP as a core data infrastructure for the clinical genomics and genetics research community.
We provide a simple flat-rate annual fee license model for application.
Commercial users will receive the latest dbNSFP data during their effective license period upon each release.
Commercial users can also evaluate dbNSFP commercial branch data with free single variant query at dbNSFP Web Service.
Personal Use
Personal users are recommended to access dbNSFP data via dbNSFP Web Service without the need of registration.