Download

• dbNSFP (a-branch) is free for academic and non-commercial use under the CC BY-NC-ND 4.0 license.

  • Please first register with dbNSFP using your academic institutional email to receive the dbNSFP Access Code

  • Then use the Access Code to request a download for the current or past versions of dbNSFP. The download links will be sent to your registered email automatically.

Data Format and Usage

• We provide dbNSFP per-chromosome variant files and gene table in a zip file with the search_dbNSFP Java program, which is specifically designed to search dbNSFP content using SNVs, transcripts and protein IDs in various formats and different genome builds. 

  • This is the standard file format of dbNSFP to minimize the development required to adapt the latest dbNSFP data to current tools and platforms.

• We also provide dbNSFP variants of all chromosomes in one large BGZF file for the convenience of Ensembl VEP and SnpSift users to run it locally.

• Some dbNSFP content (may not be up-to-date though) can also be accessed through Ensembl VEP web version, OpenCRAVAT, ANNOVAR, KGGSeq, VarSome, UCSC Genome Browser's Variant Annotation Integrator, SnpSift and HGMD.

Explore and Search dbNSFP data

• We developed a web query service to search and explore complete dbNSFP data of the current version without the need to download. 

  • Academic users can access this service for free to query a-branch data using their dbNSFP Access Code.

  • Non-Academic users can apply here for free trial access to the c-branch data.

Commercial Use

• License fees apply for commercial use of dbNSFP (c-branch). This model ensures the continued development and maintenance of dbNSFP resources for both academic and industry users. 

  • Please refer to the License page for the application form and the scope of the commercial use of dbNSFP data.

  • dbNSFP commercial users will receive the latest dbNSFP releases during their effective license period.