Download dbNSFP for Academic and Non-commercial Use
dbNSFP is free for academic and non-commercial use under the CC4-NC-NDR license. Please complete the academic user registration to receive the download instruction.
Our academic registration process uses a list of domains for automated screening and distribution of dbNSFP to academic and non-commercial users. However, receiving dbNSFP files from any source does not automatically grant the rights to use it freely in your organization. Please review our commercial use policy at License.
Download dbNSFP for Commercial Use
License fees are applicable for commercial use of dbNSFP. This model ensures the continued development and maintenance of dbNSFP resources for both academic and industrial users. If you are interested in using dbNSFP in your company, please review our commercial license application form.
Please Note: Some scores in the dbNSFP academic version have individual licensing requirements for commercial use; therefore, we cannot include them in the dbNSFP commercial version.
Use dbNSFP Web Query Service
We provide a web service to quickly query a small number of variants in latest dbNSFP data without the need to download.
Academic users can access this service for free after academic user registration.
Non-academic users can access the dbNSFP commercial version after applying for a free trial.
Use dbNSFP to Annotate a Large Number of Variants Locally
We provide two ways to use the dbNSFP database locally:
Using the accompanying Java program: search_dbNSFP bundled with dbNSFP files (in the downloaded zip file) to annotate variants from different human genome reference builds with various name formats.
We also provide dbNSFP files in bgzip format with tabix indexes, ready to run with VEP locally (with the latest version of dbNSFP plugin) and SnpSift.